While walking through the picturesque historic centre of Florence, one sign or symbol will surely catch your eye. A red stylized lily on a white background, commonly known as the Giglio of Florence representing ‘the city of flowers’. Everywhere you look, you’ll find it, on the Duomo, Palazzo Vecchio in Piazza della Signoria, Sculptures, Signages, Motifs, Window Grills, even Manhole covers and Dustbins. The appearance and representation of Giglio speak of its historical significance and cultural identity in the city of Florence which spans generations.
An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4
This paper presents a new methionine-directed activity-based protein profiling (ABPP) platform to identify and target functional methionine sites on proteins for covalent ligand discovery.…